Comparing benefits of every-third-day vs. daily low-dose aspirin therapy (2001)

 (nlm.nih.gov)

34 points | by walterbell 1 day ago

6 comments

  • sathomasga 1 day ago
    Follow up in 2015 with essentially the same conclusions:

    "Acetylsalicylic Acid Daily vs Acetylsalicylic Acid Every 3 Days in Healthy Volunteers: Effect on Platelet Aggregation, Gastric Mucosa, and Prostaglandin E2 Synthesis"

    https://accp1.onlinelibrary.wiley.com/doi/abs/10.1002/jcph.6...

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    • chr15m 1 day ago
      Thanks for sharing this!
  • OptionOfT 20 hours ago
    I got prescribed 30 days of low-dose aspirin after my hip replacement to prevent clotting. 81mg. At least I didn't have side effects, the other anti-inflammatory made my brain foggy.
  • polishdude20 1 day ago
    What's the benefit of taking aspirin regularly anyways?
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    • DougN7 1 day ago
      It’s supposed to help reduce clotting, and thus help a bit to prevent a heart attack, at least that’s what I understood from my heart doctor. Generally you’d take the 81mg “baby aspirins” for this, not a full adult dose.
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      • Keyframe 1 day ago
        or in this case one fizzy tablet every three days? Are tehre people doing this long term? Doesn't sound all that compatible with colon.
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        • DougN7 1 day ago
          After a heart procedure my doctor told me to take the 81mg daily for the rest of my life. It’s been about 20 years now, with no side effects that I know of.
  • walterbell 1 day ago
    This could mitigate side effects (stomach ulcers, bleeding) while retaining most of the benefits.
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    • chr15m 1 day ago
      Some research suggests the stomach bleed risk comes from the platelet inhibition itself, which would mean you can't have the good effect without the bad.
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      • chr15m 1 day ago
        Hang on, the 2015 study suggests otherwise.

        Daily dose suppressed PGE2 while 3-daily dose didn't.

        > Since PGE2 is involved in gastric healing, we understand that this new approach could be safer and as efficient as the standard daily therapy on a long-term basis.

    • abrookewood 1 day ago
      So in one case you get triple the daily dose (325 mg vs 81mg) every three days. I'm not sure how that would mitigate side effects?
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      • walterbell 1 day ago
        From the summary, only small difference between 81mg daily vs 81mg every 3 days, i.e 87% benefit at 33% averaged dosage.

          325mg every third day: 86% inhibition
  81mg per day:          85% inhibition
  81mg every third day:  74% inhibition
  • hn_throw2025 15 hours ago
    I would recommend asking your medical practitioner about enteric-coated forms.

    I am nearly nine months into NSAID gastritis from only a week of daily 75mg soluble Aspirin.

    I have had more painful acute illnesses in the past, but the grind of a long-term illness is new to me and it has been absolutely terrible.

  • dzdt 1 day ago
    Is there a good heuristic now for which things on nih.gov.or cdc.gov are real science?
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