Cells use 'bioelectricity' to coordinate and make group decisions

(quantamagazine.org)

159 points | by marojejian 20 hours ago

17 comments

  • jupiterelastica 11 hours ago
    For those interested in more details and quite mind blowing examples, here is a fascinating interview with Michael Levin (one of the researchers mentioned in the article).

    https://youtu.be/c8iFtaltX-s?t=4751

    Start at 1:19:11, the stuff before is him talking about biology, but from an intelligence perspective. After this time stamp is his retrospective on his bioelectricity research over the years, showing also examples of how they got a frog embryo to produce eyes, and many more things.

    • joel_liu 11 hours ago
      Thanks for sharing this timestamp - Levin's retrospective on bioelectricity research is compelling. What fascinates me most is how his work challenges the gene-centric view of development. The experiments showing bioelectric patterns can override genetic instructions (like inducing eye formation in non-eye tissue) reveal a whole layer of morphogenetic information we're just beginning to understand.
      • nandomrumber 9 hours ago
        I don’t believe genetics ever claimed to provide a theory of why eyes grow where eyes grow.

        The cells in your eyes have exactly the same DNA as the cells in your big toe, so developmental morphology cannot be explained with DNA alone.

        • mojosam 6 hours ago
          > I don’t believe genetics ever claimed to provide a theory of why eyes grow where eyes grow.

          That’s the whole point of developmental biology, to show how features of the human body form and develop based on gene expression, the timing of which during embryonic and fetal development itself is dictated by your genes.

          If not your genes, what else would determine why you have eyes in about the same place in your head as every other human?

          > The cells in your eyes have exactly the same DNA as the cells in your big toe, so developmental morphology cannot be explained with DNA alone.

          Sure it can, because while every cell has essentially the same DNA, the expression of genes differs between cells, which is what causes cells to differentiate. And this differentiation also controls development; look up the Hox genes as an example.

          • kevlened 2 hours ago
            He's changed wild-type planarians to grow the heads of other species. It reverts after a few weeks, because the system has error-correcting mechanisms, but the DNA of these worms is unchanged.

            He once compared tinkering with DNA as pulling out a soldering iron to fix a software bug.

            In the case of morphology, DNA may not be the best level of abstraction. It's certainly possible, just as one can use chemistry for social problems, but for some problems, affecting cell-to-cell communication may be a more direct path.

          • zmgsabst 3 hours ago
            Your last paragraph is their point: genes are regulated to produce that effect. The genes themselves aren’t doing it, but eg diffusion of chemical signals to inactivate genes.

            Morphology is determined by the combination of genes, chemical signals, original cell machinery, and apparently electrical signals. But we never believed that genes determined morphology alone, eg, we know that chemical signals can cause anomalies.

            • mmooss 1 hour ago
              > Morphology is determined by the combination of genes, chemical signals, original cell machinery, and apparently electrical signals. But we never believed that genes determined morphology alone, eg, we know that chemical signals can cause anomalies.

              For the consistent parts - eyes may be different colors but are overwhelmingly consistent - what else could be the ultimate cause but DNA? For example, if those chemical signals, cell machinary, and electrical signals produce the same results billions of times over 200,000 years, then they must function the same overall. How does that happen if the chemical signals, cell machinary, and electrical signals aren't determined, even if indirectly, by DNA?

          • mmooss 2 hours ago
            > If not your genes, what else would determine why you have eyes in about the same place in your head as every other human?

            Theoretically, it could be second or much higher order effects that result from genes. It could be a combination of complex factors - the environment in the womb, nutrition, behavior by the mother, etc. - that eventually trace back to DNA.

            Also, is it literally true that DNA is the only thing that's consistent (in these respects) between all generations of Homo sapiens?

        • RaftPeople 4 hours ago
          > The cells in your eyes have exactly the same DNA as the cells in your big toe

          Is that true?

          I know that cells in the brain have significant variability in DNA, but not really aware of what non-neuronal and non-brain cells in general typically have.

          • arrosenberg 4 minutes ago
            Every cell in your body (excepting red blood cells) have a complete copy of your genome. What differs is which portions are activated.
    • jnpnj 6 hours ago
      Great link, he also discusses the start of his lab. The discovery of bioelectricity induced eye "modeling" was ..kinda crazy.

      Also, I've been trying to find people to discuss this, so I set up a discord server:

      https://discord.gg/gdaSgDgC5y

      if anyone is interest (note: i'm just a software engineer, not in biomedicine or bioelectricity yet). if there are already long running discord servers then i'd rather join these instead :)

    • seanclayton 5 hours ago
      Just want to say, the "stuff" before is absolutely necessary groundwork to even begin comprehending the implications.
  • Torkel 14 hours ago
    Here's a study from 2023 where they apply external electricity to improve healing rate of wounds:

    https://pubs.rsc.org/en/content/articlelanding/2023/LC/D2LC0...

    It enabled healing of diabetic wounds that are otherwise hard to heal.

  • marojejian 20 hours ago
    Even since reading about Michael Levin's work, I've been sold that there is a lot going on in terms of bioelectricity outside of neurons. But I haven't seen that much progress. This is one interesting, albeit simple example.

    >In this way, bioelectrical flow across cell membranes lets tissues test which cells are the least healthy and mark them for extrusion. “They’re always pushing against each other and bullying each other. And what they’re doing is probing each other for which one’s the weakest link,” Rosenblatt said. “It’s a community effect.”

    This fits with my model of how high levels of cooperation succeed in biology. Even in a community as homogeneous as cells you have the risk of defectors (cancer), or just poor members. As such you need a process to continually test your community members.

  • xaedes 1 hour ago
    Robert O. Becker also studied this. His book "The Body Electric" (1985) was quite interesting. Nice to see some more recent research into this topic.
  • mojosam 5 hours ago
    This is classic Quanta Magazine sensationalism. Here's what the study actually said:

    As cells in epithelial tissue get crowded, their membranes start to allow more sodium ions to enter, which makes the cell more electrically positive (depolarization). The cells try to counter this, but cells with insufficient stored energy (ATP) will struggle to do so, and will lose water through their membranes, causing them to shrink, which causes them to signal their neighbors to extrude them.

    So there's no "group decisions" being made, no "coordination" between cells using "bioelectricity". Yes, all cells rely on electrical potentials across their membranes for normal functioning, potentials that they have to maintain. That's all the involvement of electricity here.

    And the only "decision-making" happening here is within a single cell, but of course cells don't "make decisions', cells are little machines, and part of the mechanism for epithelial cells -- a mechanism that works in part using chemistry and electricity -- includes the cell signaling that it needs to be extruded in certain circumstances, like shrinkage.

  • mjanx123 12 hours ago
    Electricity is the core of a single cell functionality as well, most biomolecules are on the exact boundary between a conductor and an insulator (and likely switch the state based on other molecules binding, pH, etc). A group of cells electricity is a higher level abstraction of that.

    https://medium.com/the-physics-arxiv-blog/the-origin-of-life...

  • jeffybefffy519 14 hours ago
    Could this lead into how there are people who thing non ionising radiation sources affect them?
    • nandomrumber 8 hours ago
      One acquaintance, after years of trying to work out what was wrong and believing EM missions may play a role turned out to have hemochromotosis (genetic disorder characterized by excessive intestinal absorption of dietary iron, resulting in a pathological increase in total body iron) which is fixed by regular blood donations.
      • Noaidi 6 hours ago
        You’re making an assumption here that it was not the increased iron in her body that made them more sensitive to electromagnetic fields. I mean, I’m not saying it’s true or not, but that’s the mistake you’re making in your argument.

        I think many people who don’t have EMF sensitivity find EMFs something easy to say is the cause their health issues, but they approach how to figure it out if it is true with zero scientific thought.

    • Noaidi 6 hours ago
      Yes, I think it is. And I am one of these people who are sensitive to electromagnetic fields. Both radio frequency and lower frequency magnetic and electric fields.

      No, I’m not running around with a tinfoil hat on thinking that it’s going to kill me, but it does cause me, insomnia, nightmares, and a worsening of my mood disorder.

      The problem is since voltage gated ion channels are also associated with mood disorders[1] and are, I believe, how EMF’s effect certain people, then it’s easy to play our sensitivity off as just our mood disorder.

      [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC3646240/

  • simmanian 3 hours ago
    Michael Levin's ontology (that the body basically acts as pointers to the mind in Platonic Realm) is so crazy that I want it to be true.
  • mbeex 8 hours ago
    From a layman's perspective, another interesting (somewhat related?) example of a long-range effect that is not determined by neurons themselves (also a recent Quanta article: https://www.quantamagazine.org/once-thought-to-support-neuro...)
  • zkmon 9 hours ago
    It was known for a long time that some reflexes and responses are mostly spontaneous and don't require decisions from the mind. Such reactions, such as pulling away when touched a hot surface, do require muscle contraction which in turn requires electrical pulses, which indicates the presence of bio electrical charges everywhere. Can some help me understand what exactly is new here. I knew that something is new.
    • Angostura 9 hours ago
      What you are talking about is the functional use of electrical impulses to active muscle. This article is talking about electrical potential as signalling mechanism for cell health, than can be used by a tissue to eject aging or sick cells
    • gus_massa 7 hours ago
      Thats https://en.wikipedia.org/wiki/Withdrawal_reflex

      The "decition" is made by the spinal cord. It's not surprising if you imagine that the brain is an oversized part of the spinal cord.

      See also https://en.wikipedia.org/wiki/Ganglion

      • MichaelZuo 6 hours ago
        If it’s known some kind of decision making, so to speak, was happening via electrical signals in the spinal cord… why is it suprising that it happens in other types of cells too?
        • gus_massa 1 hour ago
          Neurons can do more operations than normal cells.

          If I can make a bad approximation:

          * Making circuits with normal cells is like making circuits with resistors and capacitors.

          * Making circuits with neurons is like adding transistors to the mix.

          (Please don't take this analogy too seriously, probably biologist and electricians are writing angry replies now.)

  • avonmach 4 hours ago
    Reminds me of Lakhovsky's book, The Secret of Life
  • pyaamb 12 hours ago
    makes me wonder what effect a low current flowing through the body would have on this process. would it hinder/disrupt this coordination?
    • xg15 9 hours ago
      The article describes the mechanism in some detail near the end. As I understand it, it's not really "coordination" in the sense that they exchange messages through the electricity.

      It's more that every cell has to maintain a voltage difference between the inside and outside ("membrane potential"). A healthy cell does that constantly using "ion pumps" that use chemical energy (ATP) to increase the potential.

      If that potential falls below a certain threshold, certain molecular mechanisms (voltage-sensitive ion channels) inside the cell are triggered that lead to ejection.

      Interestingly, are also other mechanisms (pressure-sensitive ion channels) that will "intentionally" make it harder for a cell to maintain its potential if it's already weakened or if the surrounding region is very crowded.

      As such, I think the effect of current would depend on the way how it would change the voltage differences of the individual cells.

      • manmal 7 hours ago
        I wonder what the role of inflammation in all this is. It must be a major disrupter (or the effect?) of such electrical comms, with all these cytokines and fluid influx changing things around.
  • Noaidi 6 hours ago
    People can read these articles and go oh cool, but then in the same breath they will say radio frequency electromagnetic fields have no effect on human health.
  • FranklinJabar 14 hours ago
    Why not simply say electricity?
    • nosianu 9 hours ago
      Because that is useless? The physical phenomenon is so very, very different in biological systems compared to the metal-wire electricity our electrical devices are based on that they are entirely different things.

      For example, charge carriers are electrons in metal wires vs. ions in biological systems. That has huge implications, because moving around ions is a lot harder, and slower.

      In a metal wire the electrical field is established from beginning to the end, and that means that the electrons at the end start moving at pretty much the same time as the ones at the other end, no matter how long the wire. That means in a metal wire signals move at a significant fraction of the speed of light in a vacuum, because it is the speed of the electrical field and not that of the charge carriers that matters.

      In a biological system electrical fields are tiny! The way the signal propagates in an axon is much more cumbersome, expensive, and slow. Speed of signal propagation is ca. 1/2 to at most 100 m/s (for thick myelinated axons). The signal is propagated by jumping in very tiny steps along the axon's inner surface. (https://youtu.be/tOTYO5WrXFU)

      This also makes The Matrix movies' main premise about humans as batteries a little strange: Sure, there's lots of electrical activity, but it is in trillions of very tiny places across nanometer distances. And it is created by moving ions around (at great energy cost).

      So anyway, what actually physically happens in an electrical grid of metal wires, or in a biological system are vastly different things. It is not the same "electricity", the only thing they have in common is that electrical fields and charge carriers (but different ones) are involved. But the way it is structured, created, propagated is entirely different in both cases.

      When I asked Google out of curiosity what it had to say it showed this:

      > Despite their differences, both are fundamentally, at their core, the movement of charged particles driven by electrical potential differences.

      This is just not correct! The "the movement of charged particles" part specifically. Again, wires have one electrical field, but in biological systems propagation is entirely different, and slow, and expensive! The methods used to propagate a signal are not even remotely comparable. That's a difference not even a Radio Yerevan joke could make use of.

      • carolosf 8 hours ago
        I think in the original story of the Matrix humans were not batteries but meant to be used as biological GPUs for the machines to run upon. The studio felt that this idea might be too confusing in 1999. So that’s why Morpheus holds up a battery.
        • runlaszlorun 6 hours ago
          Oh wow. That's far less ridiculous a notion.
      • GordonS 4 hours ago
        This is very informative - just wanted to say thanks!
    • skyberrys 14 hours ago
      The article notes that bioelectricity is just referring to electricity not occuring in the heart or brain which has a different specialized name. Simply saying electricity is captures more than the cell types reported on.
      • FranklinJabar 13 hours ago
        So this is sort of.. environmentally available electrical potential in the cell? Or is it more constrained than the venues from the heart and the cell to other specific venues?
    • ggm 14 hours ago
      You're rght. Light? thats just EMF. Infra Red? Emf. Xrays? It's all EMF man.

      At least thats ITU regulated frequency bands. I wonder if the ITU regulates biogenic DC signalling frequencies?

  • nprateem 12 hours ago
    It'll blow their minds when they start researching chi kung and realise it's possible to draw in more energy by breathing and move it round the body. It's also possible to feel some kind of field around the body.

    Auras and chakras don't sound so silly now do they.

    • an0malous 5 hours ago
      I agree, I think we’re rediscovering the life force: https://labyrinths.xyz/posts/yuga-cycles-and-the-life-force

      To me the most interesting part of Levin’s research is that they can convince cells to grow two arms, two tails, etc. and when they cut off the two tails, it grows back with two tails. This is without any genetic changes, so where is the information being stored?

      Likewise there’s research that butterflies can be taught to have aversions to certain chemicals or smells in the caterpillar state, and they continue to have those aversions in the butterfly state even though they’re entire body becomes a chemical soup during the chrysalis stage. Where is that behavioral information being stored if not neurons?

      I think this is pointing to a discover that’s much more profound than the body using electricity in interesting ways. I think it’s pointing to a new force or new aspect of electromagnetism that hasn’t been discovered yet.

    • ben_w 10 hours ago
      > possible to draw in more energy by breathing and move it round the body

      We already know what haemoglobin is thanks

    • Terr_ 12 hours ago
      "It'll blow those Chemists' minds when they start researching Alchemy and they realize the incredible power of mercury and lead to rejuvenate the body and lead to an elixir of youth!"

      "It'll blow those Astronomers' minds when they start researching Astrology and the powerful effect of being born under auspicious constellations!"

      __________

      If the ancient guru knowledge is so great, what testable predictions does it offer, where "auras" are a causal mechanism?

      In other words, not: "Thou must intake the golden aura of oats and fiber by eating some, to counter the dark brown blockage of your Pu-point." The folk remedy might well solve your constipation, but it wouldn't be evidence for the mythology around it.

      • fooker 8 hours ago
        > Alchemy and they realize the incredible power of mercury

        They were just a few centuries too early!

        https://interestingengineering.com/innovation/nuclear-fusion...

        • nandomrumber 7 hours ago
          The Alchemists were right, just not ambitious enough.

          If they’d’ve started with turning hydrogen in to gold they’d’ve had more success, and we’d be a space fairing species by now.

          • fooker 7 hours ago
            Step 1: yeet mercury into a mini sun.

            If this actually works, I'm going to be convinced that some alchemist overheard an alien dude talking about this but misinterpreted it in line with contemporary knowledge.

            • ben_w 4 hours ago
              It does work, but nobody really cares because of all the radiation involved.

              Here's a paper, but given the date I have no idea if it was written by humans or by AI: https://arxiv.org/abs/2507.13461

              • fooker 2 hours ago
                Seems the radiation goes away in a decade or so, not a huge amount of time in the grand scheme of things.

                And I guess irradiated gold or a weird gold isotope would be just fine for putting in electronics that is meant to go beyond low earth orbit.

          • cindyllm 7 hours ago
            [dead]
          • runlaszlorun 6 hours ago
            It's not their fault, they didn't have lean startup and blitz scaling yet. </s>
      • nprateem 10 hours ago
        Proper hatha yoga (not the modern hijacked nonsense) is literally a predictive method to experience deeper aspects of oneself, one part of which is a greater sensitivity to energy movements and corresponding fields.

        There is already western research on kundalini, the most potent example of bioelectrical energy, and changes in energy potential experienced by meditators. Not to mention countless empirical self-reports (upon which a good scientist would keep an open mind).

        But don't let facts get in the way of your prejudices.

        • an0malous 6 hours ago
          Where can one learn proper hatha yoga?
          • nprateem 1 hour ago
            8limbs.com. Gregor Maehle has written some excellent books and has some good on-demand courses.

            Also the free lessons on aypsite.org

        • fooker 8 hours ago
          Words have meaning, don't write random things about a topic you don't understand because of cultural pride. What you have written is nonsense and demeans hatha yoga, among other things.

          > predictive method

          No

          > corresponding fields

          What field? Corresponding to what?

          > changes in energy potential experienced by meditators

          Link to mentioned research?

        • Angostura 9 hours ago
          > is literally a predictive method to experience deeper aspects of oneself, one part of which is a greater sensitivity to energy movements and corresponding fields.

          What does it actually predict? What measureable predictions can be tested?

      • djtango 10 hours ago
        It feels really great to wield the scientific method and feel supercilious to all other people and ideas that do not arise from such infallible reasoning, and sure the progress of humanity hockey sticked since empiricism took hold. But let's not forget that empiricism is limited by what we can/want/think to measure.

        Like it's pretty well accepted that breathing exercises have physiological and mental health benefits but it took decades of consumerist appropriation of yoga and other techniques before academia properly found the motivation to earnestly investigate that yes breathing exercises are indeed good for you.

        As someone who is a deep practitioner of martial arts and athletics, if the metaphors of qi gong and yoga were purely powerful visualisation aids that already provides more than enough tangible benefit. I don't need scientists to tell me that qi is good for my body - I can feel it.

        So let's keep an open mind, our ancestors were anything but idiots.

        • ben_w 9 hours ago
          > So let's keep an open mind, our ancestors were anything but idiots.

          Just not so open our brains fall out.

          Our ancestors were just like us, but fewer in number and inventing things from scratch. Miasma, spontaneous generation, Newtonian gravity, these were not people being idiots, and even though they have been shown to be wrong they are still close enough to still be useful today. Phlogiston also wasn't idiotic, but lacks utility vs being correct about oxygen.

          One of the shared ways we failed then and now is that what sounds true isn't the same as what is true; the modern easy example of this is how easily many of us get fooled by LLMs, and I suspect that's how a lot of ancient religions grew, with additions and copy-errors evolving them to be maximally plausible-sounding to a human mind.

    • renewiltord 10 hours ago
      [flagged]
  • inshard 13 hours ago
    Michael Levine really opened my mind to phase space in biology.
  • bitwize 14 hours ago
    Yes, but how do they handle Byzantine fault tolerance?
    • taneq 12 hours ago
      T-cells. :P